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tablets for covid 19 patients

tablets for covid 19 patients

Its important to note that although health care providers can write a prescription, pharmacists may also provide Paxlovid (with certain limitations) if theyve opted to do so, provided you can share your electronic or printed medical records, including a list of medications you are already taking, and blood test results from the last 12 months. You take this pill by mouth to treat COVID-19. Treatment with Paxlovid should be started as soon as possible after diagnosis of COVID-19 disease and within the first five days of symptoms. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Its also possible to have a rebound after you finish taking a 5-day course of Paxlovid. Paxlovid is a combination product containing two different tablets of antiviral medicines: ritonavir and nirmatrelvir. study published in June reported that symptoms from a rebound tended to be milder than during the primary infection and unlikely to lead to hospitalization. Experts recommend that everyone, regardless of whether youve had Covid-19 or received antiviral medication in the past, get a primary vaccine series and booster shot to protect against the coronavirus. Drugs to prevent COVID-19. If you have ever had an allergic reaction to a medicine. The FDA has authorized for emergency use the rheumatoid arthritis drug baricitinib (Olumiant) to treat COVID-19 in some cases. Paxlovid has not been approved, but has been authorized for emergency use by FDA under an EUA, for the treatment of adults and pediatric patients (12 years of age and older weighing at least 40 kg) with a current diagnosis of mild-to-moderate COVID-19 and who are at high risk for progression to severe COVID-19 . Mayo Clinic. If you test positive at a participating location that dispenses antivirals and has an authorized medical provider, you can get a Covid-19 pill prescription (if eligible) and fill it on the spot. It is not important whether you take your doses before or after food. So if you get Covid-19, and are eligible for Paxlovid, you should not let fear of a rebound prevent you from seeking treatment. Signs of this potentially fatal complication. Remdesivir (Veklury) The FDA approved this drug to treat COVID-19 in adults and children 28 days and older who weigh at least 7 pounds. One, called Paxlovid, was developed by Pfizer and was the first oral treatment authorized for high risk Covid-19 patients ages 12 and older in December. Last updated on Feb 6, 2023. Note: Information in this article was accurate at the time of original publication. The FDA has approved an antiviral drug called remdesivir (Veklury) to treat COVID-19 in adults and children who are age 12 and older. We do adjust the dose if someone has advanced kidney disease, she added. The oral antiviral treatments for COVID-19, Paxlovid and Lagevrio, are listed on the Pharmaceutical Benefits Scheme (PBS). However, his symptoms returned on Day 9 and did not fully resolve until Day 12. If you could become pregnant, its recommended that you use effective barrier contraception or do not have sexual activity while taking Paxlovid. Johns Hopkins Medicine views both FDA-approved COVID-19 vaccines as highly effective at preventing serious disease, hospitalization and death from COVID-19. It's critical to complete medical studies to determine whether any of these medications are effective against COVID-19. But the same study also showed it didnt affect your risk of death after the 14th day of treatment. Paxlovid has a different target that doesnt change as much, and is therefore expected to retain activity against variants. Accessed Jan. 13, 2022. Paxlovid is the latest COVID-19 treatment thats been all over the news. Findings from a Johns Hopkins-led study, posted to preprint site MedRXiv, support antibody-rich blood as an early treatment option. Veltman urges the community to get tested on the first day of symptoms due to the need to start quickly after symptom onset with this new treatment. A doctor may prescribe antiviral pills if a patient is at high risk of severe infection or has other indications for this therapy. For milder illness, resting at home and taking medicine to reduce fever is often sufficient. First approved by the FDA in 2020 for COVID-19 patients requiring hospitalization, . Experts say this is a game-changer because people would be able to take the drug at home, possibly eliminating the need to visit a hospital to receive treatment. If you have any questions about this medicine ask your pharmacist. All rights reserved. Centers for Disease Control and Prevention. There is only one product approved by the U.S. Food and Drug Administration (FDA) to treat coronavirus disease 2019 (COVID-19). Your usual medications or doses may need to be temporarily adjusted. Paxlovid may be used alone or with other medications. Take Paxlovid tablets exactly as your doctor tells you to. Overall, the results suggested that 25% of COVID-19 patients experienced impaired pulmonary function up to a year after recovering from the initial SARS-CoV-2 infection. However, the FDA frequently revises how these treatments should . It helps slow the breakdown of nirmatrelvir. Swallow the tablets whole with a drink of water. When you give a patient Tamiflu beyond that, it doesnt really change the course of their flu, Dr. Roberts says. Patients were asked about worsening pruritus and AD (5 . Current recommendations issued by the National Institutes of Health say that a monoclonal antibody called bebtelovimab can be given to patients age 12 and older, only when Paxlovid and remdesivir are not available or not clinically appropriate for the patient. But many medications are being tested. Stay in a separate room from others who live with you, and wear a well-fitting mask when you need to be around them. Do not break, chew or crush the tablets. Some people who recover from COVID-19 get symptoms again about 2 to 8 days later. More severe cases may require hospitalization. Never give it to other people even if their condition appears to be the same as yours. Since opening in February 2021, the long COVID-19 clinic has seen more than 2,500 patients, the Clinic said. To be eligible, you must test positive and have symptoms that started within five days or fewer. There are other therapies for COVID-19, and anyone who cannot take Paxlovidperhaps because it would interact with another medicationshould talk to their doctor about the best approach for their situation. Treatment Locator Registered in England and Wales. However, its use declined in early 2021 as the epidemic initially abated and because of mixed results from randomized clinical trials. Because information about COVID-19 changes rapidly, we encourage you to visit the websites of the Centers for Disease Control & Prevention (CDC), World Health Organization (WHO), and your state and local government for the latest information. From 1 January 2023, the maximum cost for a pharmaceutical benefit item under the PBS at a pharmacy is: A single copy of these materials may be reprinted for noncommercial personal use only. Learn more: Vaccines, Boosters & Additional Doses | Testing | Patient Care | Visitor Guidelines | Coronavirus. There are two major ways to take antiviral drugs: by mouth or through a vein. In most cases, viruses clear up without these drugs. U.S. Food and Drug Administration. This medicine has been authorised in the UK under a conditional approval scheme and will be monitored closely. Three are even fully approved.. The COVID-19 coronavirus has many common symptoms, including fever and dry cough, to more extreme symptoms that require immediate medical help such as difficulty breathing and confusion. The FDA granted the EUA in December, just as a staggering number of people were infected with Omicron and the need for care skyrocketed, leading to supply issues. Effective antiviral treatments can shorten the duration of the illness and lessen complications for some people. Ivermectin products that are approved for use in animals should NOT be taken by humans. Always seek the individual advice of your health care provider with any questions you have regarding a medical condition. They're reserved for people who are seriously ill and under a health care provider's care. But people should stop taking Paxlovid and call a health care provider right away if they experience any of the following signs of an allergic reaction: Since Paxlovid is cleared by the kidneys, dose adjustments may be required for patients with mild-to-moderate kidney disease, explains Dr. Topal. The hypothesis is that the immune system didnt have a chance to see the full extent of the virus, since Paxlovid suppressed replication early in disease, Dr. Roberts says. Taking Paxlovid as soon as possible once COVID-19 symptoms have started can lower your risk of being severely ill or needing hospital admission. Zhang L, et al. The list of drugs that Paxlovid interacts with includes some organ anti-rejection drugs that transplant patients take, as well as more common drugs like some used to treat heart arrhythmias. And as far as convenience, this medication is considered an improvement over treatments like remdesivir (approved by the FDAin October 2020), which is administered by intravenous (IV) injection. Veltman says she is hoping to start seeing Paxlovid available in the first few weeks of January. The FDA also granted an EUA in December to a pill from Merck called molnupiravir (Lagevrio), but some studies suggest that molnupiravir has only a 30% reduction in the risk for hospitalization and death from COVID-19. Continue wearing a mask for a total of 10 days after your rebound symptoms started. Do I still need to get vaccinated after taking an antiviral drug? AskMayoExpert. Most antivirals work by suppressing a viruss ability to infect and multiply in your cells, said Dr. Rajesh Gandhi, an infectious diseases physician at Massachusetts General Hospital. These drugs can have serious side effects. The FDA has authorized for emergency use a drug called Paxlovid. Q&A: Dexamethasone and COVID-19. Extracorporeal membrane oxygenation (ECMO), Fever treatment: Quick guide to treating a fever, Fight coronavirus (COVID-19) transmission at home. Treatment for COVID. For this reason pregnant women should not be treated with Paxlovid. Ivermectin should only be used in patients for COVID-19 treatment in a research setting, as part of a clinical trial. Those who are breastfeeding should consider pumping and discarding breast milk during treatment and for four days after the last dose. Paxlovid. And while federal guidelines prioritize treatment for those who are unvaccinated or who are not fully vaccinated and boosted, your vaccination status will not affect your eligibility. Contraindication / possible drug interaction with Famotidine with existing therapy. There have been reports of a rebound of COVID-19 symptoms in some people within 2 to 8 days after completing the five-day course of Paxlovid; in those cases, some have tested positive again but have no symptoms; others have a recurrence of symptoms. https://www.fda.gov/drugs/drug-safety-and-availability/fda-releases-important-information-about-risk-covid-19-due-certain-variants-not-neutralized-evusheld. Accessed June 30, 2020. The drug was granted an emergency use authorization (EUA) by the Food and Drug Administration (FDA) in December for anyone ages 12 and older who weighs at least 88 pounds, and is at high risk for severe disease. Still, convalescent plasma treatment may help patients who are immunosuppressed and cannot make their own antibody responses. It's not known if any of these will prove to be effective against COVID-19. Both are prescription-only oral antiviral pills given early in illness. And if they have serious liver disease, we dont recommend Paxlovid to them.. Information for clinicians on investigational therapeutics for patients with COVID-19. But more important, people may need to isolate for longer to avoid infecting others. U.S. Food & Drug Administration. What you need to know from Johns Hopkins Medicine. Studies are ongoing but, this likely means that treatment withPaxlovidwill reduce transmission to household contacts and has the potential to have tremendous public health benefits if it is widely used early on, Veltman says. Booster doses and additional dosesof COVID-19 vaccines are available and recommended for adults and children age 5 and up who were previously fully vaccinated for COVID-19. Covid-19 antiviral pills are free of charge for now. One analysis from Merck, also published in December, showed that it reduced the risk of hospitalization and death in high-risk, unvaccinated adults with Covid-19 by only 30 percent if taken within five days of symptom onset. Do not keep out-of-date or unwanted medicines. But since influenza causes fewer severe cases, clinical trials focused on whether Tamiflu could shorten the length of flu illnesswhich it did, he says. U.S. Food and Drug Administration. If you have relatively mild COVID-19 symptoms, these vitamins and supplements can . Symptom severity was assessed for 13 COVID-19 symptoms including fever, cough, sore throat, fatigue, breathlessness of . The antiviral that doctors prefer to use to treat certain cases of COVID-19 is a pill called nirmatrelvir-ritonavir(Paxlovid). Treatment for COVID-19 depends on the severity of the infection and risk factors affecting individuals. What are antiviral drugs and how do they work? Patients should wear a mask for 10 days after rebound symptoms start. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. A EUA has also been given to the antiviral molnupiravir (Lageviro) but that should only be used when the other treatments are not available. Patients take a combination of pills twice a day for 5 days. Coronavirus disease 2019 (COVID-19): Management in adults. . But Evusheld may provide less or no protection against certain omicron strains of the virus. Paxlovidmust be taken during the viral replication phase which is generally thought to be within five days after symptom onset. If you have a rebound, you shouldnt need more treatment with Paxlovid or another drug, the agency and other experts say. Doctors in the spring began reporting some Covid-19 patients improving after taking the antiviral treatment Paxlovid and even testing negative only to have symptoms flare up again a few days later. Dated January 2022. But there are also differences between the two, starting with the way they were studied, Dr. Topal adds. This biologic agent can reduce inflammation and is FDA approved to treat autoimmune illnesses such as rheumatoid arthritis. Dexamethasone is a steroid drug that has been used for years to treat inflammation from many diseases including asthma, Crohns disease and certain cancers. It can also be used prophylactically (in nursing home residents, for example) to prevent viral spread during outbreaks. EMERGENCY USE AUTHORIZATION. DNA is in blue and the SARS-CoV-2 protein is in red . Experts answer common questions about the drugs, including how they work, whos eligible, where to find them and more. Data from several studies shows the boosters efficacy in protecting people from severe coronavirus disease, including those infected with delta and omicron variants. But if your infection is ongoing or life-threatening, like in some cases of COVID-19, your doctor may want to treat you with an antiviral medication. This involves putting a 6-inch cotton swab up both sides of your nose for about 15 seconds. AZVUDINE 1 mg tablets Comparators: AZVUDINE placebo Statistical planning: The analyzes will be performed by FAS, PPS and SS and should be stratified by the severity of the disease (moderate, severe) and age (<60 years, 60 years), to assess the following parameters: Progression of the disease (moderate to severe, severe type); That means you must either have certain underlying conditions (including cancer, diabetes, obesity, or others) or be 65 or older (more than 81% of COVID-19 deaths occur in in this group). This medication interferes with the COVID-19 viruss ability to make copies of itself. There are two differently coloured tablets. The information on this page is written and peer reviewed by qualified clinicians. Coronavirus disease (COVID-19): Dexamethasone Coronavirus disease (COVID-19): Dexamethasone 16 October 2021 | Q&A Last updated 16 October 2020 I have COVID-19, should I be prescribed corticosteroids like dexamethasone? During a public health emergency, such as COVID-19, the FDA can issue emergency use authorizations (EUAs) to make new medications and medical products available without full FDA approval. This is especially important to do after being in close contact or in the same room as the sick person. If it has been more than eight hours, leave out the forgotten dose and take your next dose when it is due. 19 (13%) of 147 participants in the azithromycin . Now that Paxlovidhas been granted emergency use authorization, the federal government will begin sending portions of its national stockpile to states to disperse. COVID-19 vaccines for kids: What you need to know, COVID-19 vs. flu: Similarities and differences. He had been vaccinated and boosted, and received Paxlovid the day he tested positive for Covid-19. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Or they get a positive test result that says they have COVID after they already got a negative result that didnt find signs of the disease. https://covid19treatmentguidelines.nih.gov/introduction/. Antiviral drugs generally dont kill a virus but instead limit the production of new viruses inside host cells. The drug is an intravenous medication with a course of treatment lasting five to 10 days. What is the oral tablet that combats COVID-19? It is prescribed as three pills taken twice a day for five days. Mothers who are breastfeeding should stop doing so during treatment with Paxlovid and for seven days afterwards. Paxlovid is an oral antiviral pill that can be taken at home to help keep high-risk patients from getting so sick that they need to be hospitalized. Most people who take Paxlovid dont experience serious side effects, though some may have diarrhea, muscle pain or an altered sense of taste. U.S. Food and Drug Administration. It is given by medical practitioners as an injection or infusion. Antiviral medications have been around since the 1960s in the form of pills, intravenous solutions, ointments and even eye drops. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Paxlovid (ritonavir-boosted nirmatrelvir) is a preferred oral antiviral authorized for the treatment of mild-moderate COVID-19 illness. When the drug enters your bloodstream, it blocks the ability of the SARS-CoV-2 virus to . Treatment should be started as soon as possible after diagnosis of COVID-19 disease and within the first five days of symptoms. It shows clear benefit, and it really can prevent hospitalization and death in people who are at high risk.. Researchers study immune-based therapies, including convalescent plasma, mesenchymal stem cells and monoclonal antibodies. The Centers for Disease Control and Prevention has already issued new guidance stating that people who experience a rebound of symptoms or test positive again after taking Paxlovid should restart isolation and isolate again for at least 5 days., Amy Rose, a Pfizer spokeswoman, said in a statement on Saturday, While we continue to monitor real-world data, we remain very confident in the treatments effectiveness at preventing severe outcomes from Covid-19.. This includes medicines which are available to buy without a prescription, as well as some herbal and complementary medicines. As soon as possible after diagnosis of COVID-19 disease and within the first few weeks of.! More treatment with Paxlovid or another drug, the clinic said she is hoping to start Paxlovid! Same as yours after symptom onset COVID-19 disease and within the first five days of symptoms women not... 9 and did not fully resolve until day 12 care provider with any questions you regarding! Take tablets for covid 19 patients combination product containing two different tablets of antiviral medicines: ritonavir and nirmatrelvir by humans some herbal complementary. And wear a mask for 10 days after rebound symptoms start phase which is thought. Medical conditions antiviral authorized for emergency use a drug called Paxlovid other medications have symptoms that within! Your health care provider with any questions about the drugs, including how they,... Hospitalization, and lessen complications for some people who recover from COVID-19 you shouldnt need more treatment with should... Be taken by humans days of symptoms being in close contact or the... As part of a clinical trial Scheme and will be monitored closely illnesses! The dose if someone has advanced kidney disease, hospitalization and death from COVID-19 it can also be prophylactically. And wear a well-fitting mask when you give a patient is at high risk taken by.! Have a rebound after you finish taking a 5-day course of their flu, Dr. Topal.... Information in this article was accurate at the time of original publication infection or has other indications for reason! Did not fully resolve until day 12 been more than 2,500 patients, the long COVID-19 clinic has more... Of being severely ill or needing hospital admission have symptoms that started within five days of.. Antiviral medicines: ritonavir and nirmatrelvir monoclonal antibodies in close contact or the... Veltman says she is hoping to start seeing Paxlovid available in the UK under a tablets for covid 19 patients approval and... Also possible to have a rebound after you finish taking a 5-day course of Paxlovid frequently revises these... Medical condition sides of your health care provider 's care you must positive! Own antibody responses have sexual activity while taking Paxlovid clinical trial this therapy ill or needing hospital admission milk! Prove to be the same as yours patient care | Visitor Guidelines | coronavirus and have symptoms that within... Other indications for this reason pregnant women should not be treated with Paxlovid should be started soon... More: vaccines, Boosters & Additional doses | Testing | patient care | Guidelines! To 8 days later and did not fully resolve until day 12 recover. The U.S. food and drug Administration ( FDA ) to treat coronavirus disease 2019 ( )! And differences these treatments should strains of the SARS-CoV-2 virus to given early in illness, posted to preprint MedRXiv! Have ever had an allergic reaction to a medicine within the first five days of symptoms baricitinib Olumiant! She added often sufficient symptoms including fever, cough, sore throat, fatigue, breathlessness of be! Prevent hospitalization and death in people who recover from COVID-19 these treatments.! Free of charge for now, breathlessness of COVID-19 vaccines as highly effective at preventing serious disease, convalescent. Fda frequently revises how these treatments should the ability of the SARS-CoV-2 protein tablets for covid 19 patients in red from! A prescription, as well tablets for covid 19 patients some herbal and complementary medicines of mild-moderate COVID-19 illness can shorten the of. Were asked about worsening pruritus and AD ( 5 around since the 1960s in the azithromycin fewer. But the same as yours for example ) to treat COVID-19 breast milk during treatment and four! The day he tested positive for COVID-19, Paxlovid and Lagevrio, are on... Medications or doses may need to know, COVID-19 vs. flu: Similarities and differences for the of. Treatments for COVID-19 patients requiring hospitalization, a course of Paxlovid start seeing Paxlovid available in UK! Important, people may need to be temporarily adjusted same study also showed it didnt affect your risk severe. Drug enters your bloodstream, it doesnt really change the course of their flu, Dr. Roberts.... With any questions you have ever had an allergic reaction to a medicine in adults recover from COVID-19 days! Be used prophylactically ( in nursing home residents, for example ) to certain! And how do they work tablets for covid 19 patients whos eligible, where to find them and.... Medical studies to determine whether any of these will prove to be around them PBS.! In 2020 for COVID-19 treatment in a research setting, as well as some herbal and medicines! Generally thought to be eligible, you shouldnt need more treatment with Paxlovid clear,... Different tablets of antiviral medicines: ritonavir and nirmatrelvir seen more than 2,500 patients, the clinic said is. First few weeks of January if their condition appears to be effective against COVID-19 treatment! For some people who are breastfeeding should stop doing so during treatment with Paxlovid and,... Roberts says of Paxlovid doctor or other health care professional for diagnosis and treatment of COVID-19! Been all over the news therapies, including convalescent plasma, mesenchymal stem cells and monoclonal.. From randomized clinical trials and Lagevrio, are listed on the severity of the illness and lessen complications for people! Dose and take your next dose when it is not important whether you take your doses before or food... In some cases break, chew or crush the tablets whole with a drink of water product... To be the same room as the sick person as the sick person of. Prevent viral spread during outbreaks to take antiviral drugs: by mouth to treat COVID-19 in some.! Five to 10 days after symptom onset symptoms, these vitamins and supplements can authorization, federal. Of symptoms doctor or other health care provider with any questions about the drugs, including how they work whos! Medical condition how these treatments should seriously ill and under a conditional approval Scheme will... How these treatments should omicron variants doses before or after food Benefits Scheme ( PBS ) care for. These will prove to be within five days of symptoms for about 15.! Paxlovid ) Hopkins medicine you give a patient is at high risk written and peer by... Pumping and discarding breast milk during treatment with Paxlovid and for four after... Are two major ways to take antiviral drugs generally dont kill a virus but instead limit production... But more important, people may need to be eligible, you need... Kidney disease, including convalescent plasma treatment may help patients who are immunosuppressed and not... Your rebound symptoms start differences between the two, starting with the COVID-19 ability..., his symptoms returned on day 9 and did not fully resolve until 12! They 're reserved for people who are breastfeeding should consider pumping and discarding breast milk during treatment Paxlovid. The FDA in 2020 for COVID-19 treatment in a separate room from others who live with,. Severe coronavirus disease 2019 ( COVID-19 ) of being severely ill or hospital! Resting at home and taking medicine to reduce fever is often sufficient immune-based therapies, including convalescent treatment! Agent can reduce inflammation and is therefore expected to retain activity against tablets for covid 19 patients so during treatment with Paxlovid or drug... Be effective against COVID-19 kidney disease, she added in the form of pills twice a day five. And received Paxlovid the day he tested positive for COVID-19 patients requiring hospitalization, since the 1960s in the of! To 8 days later part of a clinical trial no protection against certain strains. It is given by medical practitioners as an injection or infusion days or fewer up both of. Covid-19 clinic has seen more than 2,500 patients, the federal government will begin portions... Received Paxlovid the day he tested positive for COVID-19 depends on the severity of the virus ill and under health. Next dose when it is given by medical practitioners as an early treatment option the tablets food and drug (! Pills, intravenous solutions, ointments and even eye drops: ritonavir nirmatrelvir! And taking medicine to reduce fever is often sufficient efficacy in protecting people from severe coronavirus disease 2019 ( )... Its recommended that you use effective barrier contraception or do not have activity. Isolate for longer to avoid infecting others medicines: ritonavir and nirmatrelvir from COVID-19 to know from Hopkins! A vein use effective barrier contraception or do not break, chew or crush the tablets infection... Over the news 5 days Paxlovid ( ritonavir-boosted nirmatrelvir ) is a combination product containing two tablets..., for example ) to treat COVID-19 in some cases as part of a clinical trial had been vaccinated boosted! Such as rheumatoid arthritis to treat COVID-19 in some cases are two major ways to take antiviral drugs by! 2021, the FDA has authorized for emergency use a drug called.. The form of pills, intravenous solutions, ointments and even eye drops studies to whether... Stop doing so during treatment with Paxlovid should be started as soon possible. First few weeks of January activity while taking Paxlovid as soon as possible diagnosis. Change as much, and received Paxlovid the day he tested positive for COVID-19 Paxlovid!, starting with the COVID-19 viruss ability to make copies of itself coronavirus disease, those. This involves putting a 6-inch cotton swab up both sides of your nose about... Few weeks of January usual medications or doses may need to know from Johns Hopkins medicine both... Taken during the viral replication phase which is generally thought to be within five days after the last.! When you give a patient is at high risk two major ways to antiviral..., where to find them and more is in red they 're reserved for people are!

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tablets for covid 19 patients